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Research at the Faculty of Medicine

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Abrahamson, Magnus
Project: Novel protein inhibitors of cysteine proteases: structure, function and medical use
Cysteine proteases are one of the four major classes of proteolytic en............
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Abrahamsson, Per-Anders
Project: New methods for diagnosis, prognosis and treatment of prostate cancer
The incidence of prostate cancer (PC) is increasing world-wide, ............
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Agace, William
Project: The role of chemokines in intestinal leukocyte localization and function
The intestinal mucosa contains a large population of lymphocytes which............
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Agardh, Carl-David
Project: Mechanisms behind the development of diabetic microangiopati
The molecular pathophysiology of diabetic complications is still not f............
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Ahrén, Bo
Project: Islet hormone secretion under normal conditions, in diabetes and in obesity
Type 2 diabetes is a commom disease predisposing to a number of associ............
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Albin, Maria
Project: Exposure to carcinogenic aromatic amines and DNA-damage among hairdressers: monitoring of exposure and early effect, and follow-up of an intervention
Aim: Potential exposure to carcinogenic aromatic amines from hair colo............
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Alvarado-Kristensson, Maria
Project: Role of SADB kinases in cell division and cancer
The group's interest is to find novel target proteins that are involve............
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Alvegård, Thor
Project: Epidemiological studies of incidence, risk factors and prevention of selected malignancies
Cancer epidemiology is often divided into descriptive, analytical and ............
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Anckarsäter, Henrik
Project: Early onset behaviour DISorders across diagnostic CATegories (DIS-CAT)
Childhood disruptive behavioural disorders include conduct disorder, o............
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Andersson, Roland
Project: Pancreatic cancer - experimental and clinical studies
Pancreatic cancer is the 4th cause of death in cancer and still associ............
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Andersson, Tommy
Project: Wnt-5a as a target for counteracting tumor metastasis
Our studies are focused on the revelation of Wnt-5a-induce............
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Andréasson, Sten
Project: Further development of new electrophysiological methods for clinical and experimental studies in families with hereditary eye disorders and in drug-induced ocular disorders
Retinitis pigmentosa is the most frequent reason for severe visual han............
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Areschoug, Thomas
Project: Bacterial disease mechanisms: subversion of macrophage immune receptors
Antigen-presenting cells, such as macrophages, are widely distri............
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Arheden, Håkan
Project: Studies of ischemic heart disease using magnetic resonance imaging
The differentiation between viable but hypo-functioning myocardium (i.............
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Axelson, Håkan
Project: The role of Notch signaling in normoxic and hypoxic tumor cells
The building of a multicellular organism is the result of differentiat............
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Axelsson, Irene
Project: Nutrient intake: effects on growth metabolism during infancy and childhood. Celiac disease and Obesity During infancy. .
We study nutrient intake, growth and metabolism during infancy and chi............
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Baldetorp, Bo
Project: Studies at protein level, on human cancer cell lines and malignant melanomas for the identification of biomarkers for metastasizing and targeted therapy.
The aim of the project is to find biomarkers for malignant melonoma wh............
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Batra, Satish
Project: Nitric oxide (NO)-cyclic GMP system in female reproductive organs: hormonal regulation and role in pathophysiology of pregnancy
In the area of human reproduction, there is now considerable evidence ............
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Baumgartner, Stefan
Project: Mechanisms of bicoid mRNA gradient formation in Drosophila.
The bicoid (bcd) gene is a well-known maternal patterning gene that wa............
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Belting, Mattias
Project: Transport of bioactive macromolecules in mammalian cells: Basic mechanisms and clinical applications.
Our project addresses several key questions in modern cell biology: Ho............
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Berntorp, Erik
Project: Inhibitors in haemophilia. Genetic immunological and clinical aspects.
Haemophilia is an X-linked inherited disorder affecting coagualtion fa............
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Bjartell, Anders
Project: Evaluation of novel biomarkers to predict outcome in prostate cancer and investigation of the underlying tumor biology
Prostate cancer is the most common malignant tumor in men in our part ............
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Bjursten, Lars Magnus
Project: Cellular mechanisms in foreign body induction at implanted biomaterials
Biomaterials implanted in soft tissue evoke with few exceptions a fore............
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Björck, Lars
Project: Studies of molecular and cellular host-bacteria interactions in relation to bacterial virulence.
The relationship between a bacterial pathogen and its human host is ba............
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Björklund, Anders
Project: New restorative and neuroprotective strategies for neurodegenerative diseases: Focus on neural stem cells and recombinant viral vectors.
Stem cells and gene delivery have opened new possibilities for restora............
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Blom, Anna
Project: Inhibitors of human complement system.
The aim of our study is to gain more knowledge about regulation of hum............
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Bodelsson, Mikael
Project: Increased levels of glycosaminoglycans during septic shock: clinical and experimental investigations
Septic shock has mortality rates of 40-70% due to organ failure ............
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Borg, Åke
Project: Molecular characterization of breast cancer
Breast cancer is a heterogeneous disease in respect of genetic suscept............
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Broman, Jonas
Project: Synaptic transmission and processing of nociceptive signals in the dorsal horn
The action potentials evoked in primary afferents by noxious stimuli p............
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Brundin, Patrik
Project: Developing neural transplant technology and understanding neurodegenerative mechanisms in Parkinson's and Huntington's diseases.
Parkinson';s (PD)and Huntington';s (HD) diseases cause sever............
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Bäck, Sven
Project: 3D radiotherapy dosimetry using dosimeter gel and MRI
The gel system forms both phantom and detector and dose distributions ............
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Cardell, Lars-Olaf
Project: Toll Like Receptors and their Role in Allergy and Airway Inflammation
The overall goal of this research proposal is to enhance our understan............
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Casslén, Bertil
Project: Molecular mechanisms in pericellular proteolysis and cell migration in reproduction and gynecological malignancy
Cell migration and tissue remodeling are processes in common to reprod............
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Ceder, Yvonne
Project: The role of microRNA in the development and progression of prostate cancer
Prostate cancer is the most common malignancy in men and the leading c............
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Cenci Nilsson, Angela
Project: Cellular responses to symptomatic and neuroprotective treatments in Parkinson´s disease
Parkinson´s disease (PD) is characterized by a degeneration of dopamin............
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Christensson, Anders
Project: Determinants of renal function and consequences of early renal dysfunction on cardiovascular diseases and diagnosis of prostate cancer.
This project aims at evaluating consequences of slight to moderate ren............
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Cilio, Corrado
Project: Regulation of autoreactive T cells in autoimmune diseases
The cellular destruction in organ specific autoimmune diseases is clea............
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Collin, Mattias
Project: Immunomodulating enzymes from bacteria: virulence factors, biotechnological tools, and future therapeutics
<I>Streptococcus pyogenes</I> is an important human pathogen that caus............
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Dahlberg, Leif
Project: Joint Cartilage Monitoring in Health and Disease
Knee pain occurs in 10-60% of the working population, of which m............
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Dahlbäck, Björn
Project: Regulation of blood coagulation and endothelial cell functions by the anticoagulant protein C and Gas6-Axl pathways. Structure-function studies of a novel apolipoprotein, apoM.
Regulatory mechanisms of hemostasis and vascular biology are studied i............
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Dahlin, Lars
Project: Peripheral nerve injuries: from signal transduction to socio-economical consequences
Hand injuries affect patients at all ages, particularly young persons ............
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Danielsen, Nils
Project: Neural interfaces
Our projects are related to two main areas. The major area is Brain Ma............
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Degerman, Eva
Project: Molecular mechanisms involved in the development of type 2 diabetes with focus on insulin signalling/insulin secretion and the cyclic nucleotide signalling systems
Type 2 diabetes is characterized by defects in insulin action and secr............
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Dejmek, Annika
Project: Integration of molecular biology and morphology in cytology with special focus on in situ detection of telomerase and its components
Cytology is a rapid method to detect malignancy. With the combination ............
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Dillner, Joakim
Project: Importance of virus infections in the etiology of cancer
WHO estimates that about 18% of all cancer is caused by infections, th............
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Durbeej-Hjalt, Madeleine
Project: Laminins in development and disease
Laminins, a large family of heterotrimeric glycoproteins, are major co............
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Dykes, Anna-Karin
Project: Parent´s experiences of ultrasound during pregnancy, Normal/abnormal findings. Reactions and needs followed over time.
Obstetric ultrasound screening, in most cases, shows a normal foetus (............
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Edenbrandt, Lars
Project: Clinical Decision Support Systems in Diagnostic Imaging
To develop and evaluate clinical decision support systems regarding th............
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Edvinsson, Lars
Project: Regulation of smooth muscle receptor expression in vascular disease
Cardiovascular disorders are associated with marked alterations in the............
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Egesten, Arne
Project: Innate immune responses during mucosal inflammation
Mucosal surfaces of the the airways are challenged by potentially inva............
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Ekberg, Henrik
Project: Induction of tolerance in allogeneic and xenogeneic transplantation by blockade of costimulatory signals.
Patients undergoing transplantation for solid organ failure are forced............
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Ekblad, Eva
Project: The enteric nervous system
Intestinal activities are controlled and co-ordinated by way of neuron............
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Ekblom, Marja
Project: Expression and function of integrin receptors in normal hematopoietic stem and progenitor cells and leukemic cells.
Throughout life, enormous numbers of mature blood cells are generated ............
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Ekdahl, Charlotte
Project: Physiotherapy - therapeutic exercises and training to promote health and well-being. Assessments and interventions.
Research at the Division of Physiotherapy is mainly focused on assessm............
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Ekelund, Ulf
Project: Towards improved diagnosing and treatment of acute coronary syndrome
The ultimate goal of this research program is to improve the care and ............
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Ekerot, Carl-Fredrik
Project: Cerebellar Physiology
The cerebellum is an important centre for motor control, motor adaptat............
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Eklund, Mona
Project: Daily occupations, health and wellbeing in different populations: intervention studies and instrument development
The strain under which people live their lives alters along with socie............
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Elfgren, Christina
Project: Semantic memory and the role of the medial temporal lobe
It is important to further delineate the predictive value of subjectiv............
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Eliasson, Lena
Project: Regulation of calcium-dependent release of insulin and glucagon
The blood glucose-level is controlled by the hormones insulin an............
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Elmståhl, Sölve
Project: Cognitive function and blood pressure, disability in the elderly and healthy aging in Skane.
High blood pressure (BP)is common in the elderly and both high BP and ............
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Erfurth, Eva Marie
Project: Long-term health effects of hypopituitarism and irradiation to the central nervous system
Patients with hypopituitarism on conventional hormone treatment, but w............
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Erlanson-Albertsson, Charlotte
Project: Appetite regulation and energy balance. Importance of fat and sucrose for body and brain. Treatment strategies and development of satiety promoting functional food.
Obesity is steadily increasing in the Western world. One reason for th............
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Erlinge, David
Project: Molecular Cardiology
The extracellular nucleotides ATP, ADP, UTP and UDP are important for ............
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Fan, Xiaolong
Project: Development of adenoviral vectors for intrinsic gene expression based isolation and ex vivo expansion of human candidate hematopoietic stem cells
Due to its extensive self-renewal and multilineage differentiation cap............
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Fellman, Vineta
Project: A. Pathophysiology of GRACILE syndrome B. Diagnosis and prevention of perinatal brain damage
A. GRACILE syndrome (Fellman syndrome, MIM 603358), is an autosomal re............
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Fenyö, Eva Maria
Project: Molecular pathogenesis of human and simian immunodeficiency viruses: biological and antigenic variation.
HIV-1 biological phenotype, such as replication rate and cytopathology............
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Fernlund, Per
Project: Studies of beta-microseminoprotein and CRISP-3
Beta-microseminoprotein (MSP) is a 94 amino acid, non-glyc............
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Fernö, Mårten
Project: Prognostic and treatment predictive factors in breast cancer
Breast cancer is the most common female malignancy in Sweden (~7000 ca............
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Fioretos, Thoas
Project: Genomic characterization and functional studies of leukaemia-associated genetic changes
Leukemia typically arise because of different somatically acquired gen............
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Forslund, Ola
Project: CUTANEOUS HUMAN PAPILLOMAVIRUSES AND ASSOCIATED LESIONS:MOLECULAR BIOLOGY & BIOMARKERS
The project aims to identify human papillomavirus (HPV) associated wit............
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Fransson, Lars-Åke
Project: Supercharging proteins with heparan sulfate prevents aggregation
Protein aggregation leads to many fatal human diseases, such as Alzhei............
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Frick, Inga-Maria
Project: Studies of molecular mechanisms of importance for commensal bacteria to cause infection
Commensal bacteria colonize the human host without normally causing di............
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Gard, Gunvor
Project: Quality and effectiveness of rehabilitation plans
According to Swedish law employees sicklisted for 4 weeks or more shou............
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Garwicz, Martin
Project: Cerebellar development and the physiology of adaptive motor control
Integrative neuroscience is concerned with relationships between acti............
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Gerdtham, Ulf
Project: The Health Economics Program on Health, Health Care and Public Policy
............
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Ghosh, Fredrik
Project: Neuroretinal Transplantation
Retinitis pigmentosa and age related macular degeneration are two of t............
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Gisselsson Nord, David
Project: High Resolution Imaging of Mitotic Segregation Errors, Genetic Diversity, and Differentiation Hierarchies in Childhood Solid Tumors
Our group is dedicated to understanding the transition from normal tis............
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Giwercman, Aleksander
Project: Studies on interplay between genetic, environmental and life-style related factors in male reproductive dysfunction
Infertility is a common problem encountered in 15% of all couples. In ............
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Giwercman, Yvonne
Project: Gene-environment interaction in prostate cancer
The overall aim of the study is to evaluate the impact of sex steroid ............
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Gjörloff Wingren, Anette
Project: Life, death and signal transduction in cancer
Tyrosine phosphorylation is a key mechanism for signal transduction in............
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Gomez, Maria
Project: Vascular complications in diabetes with focus on excitation-transcription coupling mechanisms in the vascular wall
Diabetes is a lifelong, incapacitating disease affecting 246 million p............
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Groop, Leif
Project: Dissection of the genetic complexity of type 2 diabetes and the dysmetabolic syndrome
Type 2 diabetes is considered as a paradigm for a multifactorial polyg............
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Grubb, Anders
Project: Biology of cystatins. Development of new drugs against amyloidosis and multiresistant grampositive bacteria based upon the structure of cystatin C. Cystatin C-based GFR prediction equations.
We sequenced in 1981 a protein with unknown function, now called cysta............
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Grände, Per-Olof
Project: Physiological and patophysiological aspects on microcirculatory control with special reference to blood flow and tissue volume regulation and to diseases in the intensive care
Diseases in the intensive care are a most common reason for death in m............
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Gullberg, Urban
Project: Molecular cell biology of myeloid hematopoiesis and leukemia
In myeloid hematopoiesis blood cells vital for the defence against mic............
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Hallström, Inger
Project: Caring for children with long-term illness- at hospital and at home
Children are major users of health care services but are rarely consul............
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Hansson, Christer
Project: Molecular mechanisms of hypersensitivity in the skin
Allergic contact dermatitis is mediated by low-molecular organic compo............
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Hansson, Lars
Project: People with severe mental illness living in the community - care, rehabilitation and social situation
In recent decades there have been major changes in public policies, re............
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Hansson, Stefan
Project: Genetic and monoaminergic mechanism during normal pregnancy, preeclampsia and intrauterine growth retardation
5-10% of all women develop preeclampsia by the second half of gestatio............
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Hedenfalk, Ingrid
Project: Genetic and Epigenetic Mechanisms of Disease Aetiology and the Role of the Microenvironment in Hereditary Breast and Ovarian Cancer
Breast cancer is a morphologically, clinically and genetically heterog............
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Hegardt, Cecilia
Project: Isolation and characterization of putative cancer stem cells in molecular subtypes of breast cancer
Stem cells and cancer cells share several characteristics such as abil............
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Heijl, Anders
Project: Glaucoma: Treatment, diagnosis, follow-up and prevention of visual impairment
Glaucoma is a common disease using a large part of the resources in op............
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Heinegård, Dick
Project: Bone and Cartilage - Normal biology and roles in disease affecting large segments of the population
Tissues targeted in our research are cartilage and bone. We stud............
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Hellstrand, Per
Project: Signals for differentiation and growth of smooth muscle in the vascular wall
The smooth muscle cells of the vascular wall are normally maintained i............
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Herwald, Heiko
Project: Modulation of hemostatic mechanisms in bacterial infectious diseases.
Life-threatening complications from bacterial infections are a major a............
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Hesslow, Germund
Project: Mechanisms of Associative Learning in the Brain
In the type of learning first described by Pavlov and now called &quot............
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Hjalt, Tord
Project: A novel mouse model for eye- and forelimb disorders.
We study normal and morbid development of eyes and arms. Our unique mo............
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Holm, Cecilia
Project: Type 2 diabetes and lipotoxicity
Free fatty acids, derived mainly from the large triglyceride stores in............
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Holmberg, Lars
Project: Molecular and clinical studies of von Willebrand factor associated diseases
The von Willebrand factor (VWF) is a high molecular weight protein dis............
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Holmdahl, Rikard
Project: Medical Inflammation Research
We try to understand the pathogenesis of chronic inflammatory diseases............
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Hultgårdh, Anna
Project: A functioal study of extracellular matrix proteins in the atherosclerotic process
The vascular extracellular matrix is a collection of different macromo............
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Häcker, Udo
Project: Characterization of Genes Regulating Growth Factor Signaling and Cytoskeletal Reorganization during Normal and Malignant Development.
Higher animal consist of a variety of cell types and tissues. The func............
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Höglund, Mattias
Project: Genomic and gene expression profiling of bladder cancer
Bladder cancer (urothelial carcinomas) is a heterogeneous disease that............
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Höglund, Peter
Project: Therapeutic applications of dose concentration effect relationships
Pharmacokinetics and pharmacodynamics can be influenced by underlying ............
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Issazadeh, Shohreh
Project: Studying role of new signaling pathways central in tolerance induction in tissue-specific chronic inflammatory and autoimmune diseases by gene finding and targeting
The common pathway in tissue-specific chronic inflammatory and autoimm............
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Ivars, Fredrik
Project: Regulation of the T cell repertoire
The immune system is continuously exposed to certain innocuous antigen............
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Iwarsson, Susanne
Project: Center for Ageing and Supportive Environments, CASE.
The research center engages five research groups; three at the Faculty............
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Janciauskiene, Sabina
Project: The Role of Post-translational Modifications of Serpins in Pathological Conditions Characterised by a Chronic Inflammation
Serpins (serine proteinase inhibitors), proteins constituting an impo............
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Jannert, Magnus
Project: Optimal palliative care and quality of life in patients with cancer in an international perspective
The research program consists of 5 parts:............
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Jansson, Marianne
Project: Innate immunity selection mechanisms in HIV infection
Genetic variability is one of the major characteristics of HIV-1, and ............
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Jeppsson, Bengt
Project: Gastrointestinal tract mucosa - a target in many diseases
The GI tract is a multilayer defense and absorption system whose maint............
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Jernström, Helena
Project: Joint effects of genetic factors, hormones and lifestyle in relation to breast cancer: implications for risk, treatment response and prognosis
More than 7000 women are diagnosed with breast cancer annually. Ten pe............
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Johansson, Bertil
Project: Molecular genetic studies of hematologic malignancies
The somatic mutation theory of tumorigenesis postulates that genetic c............
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Jonson, Björn
Project: Diagnostic Lung Function Studies in the Laboratory and in Intensive Care. Acute Respiratory Distress Syndrome.
Advanced and unique techniques, e.g. computer controlled ventilators a............
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Jovinge, Stefan
Project: New cardiovascular therapies
The heart and the cardiomyocyte in special have been viewed as termina............
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Jönsson, Bo A
Project: Environmental, respiratory disease and exposure
Reactive, low molecular weight chemicals in the work environment cause............
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Karlberg, Mikael
Project: Neck proprioceptive, vestibular and psychological contributions to balance disorders. Development of new diagnostic and therapeutic tools.
Patients complaining of vertigo or dizziness are commonly encountered ............
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Karlson, Björn
Project: Biomarkers and self-reports in work-related stress. Cognitive functioning and recovery of work capability for patients with burnout diagnosis.
The program obtains data on stressors, stress, and psychological and/o............
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Karlsson, Magnus
Project: Determinants for Bone Mass and Architecture, Fall and Fracture, Adiposity and Cardiovascular Risk Factors in Young and Elderly with Special Attention to Physical Activity
The musculoskeletal development is gender and age dependent regulated ............
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Karpman, Diana
Project: Studies of the Pathogenesis of Hemolytic Uremic Syndrome (HUS), Thrombotic Thrombocytopenic Purpura (TTP), Vasculitis and IgA nephropathy
The hemolytic uremic syndrome (HUS) is characterized by a triad of thr............
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Kempe, Maria
Project: Polymers for biomedical applications
Elements capable of molecular recognition are demanded for a range of ............
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Kidd-Ljunggren, Karin
Project: Functional and structural analysis of hepatitis B virus (HBV) and detection of clinically important microbial mutations
Chronic infection with hepatitis B virus (HBV) can lead to progressive............
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Kirik, Deniz
Project: Cell and gene therapy based approaches for treatment of Parkinson's disease
Parkinsons disease is one of the common causes of disability in the ag............
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Kokaia, Merab
Project: Mechanisms of epileptogenesis: Gene therapy by neuropeptides, neurotrophic factors and optogenetics
Epilepsy is one of the most devastating neurological diseases affectin............
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Kokaia, Zaal
Project: Isolation and charaterization of human neural stem cells and development of transplantation strategies for functional restoration after stroke
Neural stem (NS) cells are derived from the nervous system, have capa............
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Landberg, Göran
Project: Cell cycle aberrations in human cancer
Cell cycle regulation is one of the main topics in modern tumor biolog............
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Landin-Olsson, Mona
Project: Autoimmune mechanisms in the pathogenesis of Type 1 diabetes mellitus
Type 1 diabetes mellitus is caused by certain HLA types in combination............
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Larsson, Christer
Project: Protein kinase C isoforms - potential target proteins for cancer therapy
Protein kinase C (PKC) isoforms constitute a family of closely related............
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Larsson, Elna-Marie
Project: Brain function and tissue characterization with 3 tesla magnetic resonance - diffusion, perfusion, functional activation of the brain, and spectroscopy
The introduction of 3 tesla (T) magnetic resonance (MR) with highly in............
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Larsson, Lennart
Project: Microbial metabolomics
We have specialized in developing mass spectrometry-based analyt............
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Leanderson, Tomas
Project: Analysis of immunomodulation in autoimmune/inflammatory and malignant diseases
In autoimmune/inflammatory diseases such as multiple sclerosis (MS), S............
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Leeb-Lundberg, Fredrik
Project: Cell and molecular properties of G protein-coupled receptors and their roles as targets in drug development
Communication between cells is necessary for the integration of all ph............
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Leffler, Hakon
Project: Galectins: structure, function, and roles and uses in inflammation and cancer.
Galectins are a family of proteins defined by shared sequence elements............
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Lernmark, Åke
Project: Immunogenetics of type 1 diabetes
The genetic etiology of type 1 diabetes suggest that HLA DQ is the maj............
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Lidgren, Lars
Project: Optimized materials and techniques for tissue reconstruction
The overall aim of the project is to develop improved biomaterials for............
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Lilja, Hans
Project: Diagnostic, prognostic, and biological impact in prostate cancer of the kallikrein-related and MSMB-gene products abundantly expressed and released by normal or malignant prostate cells
As biomarker levels and genetic variation in KLK3/PSA, KLK2/hK2 and MS............
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Lindahl, Gunnar
Project: Molecular analysis of host-pathogen interactions in bacterial infections
Infectious disease is the most common cause of death, globally. This s............
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Lindblad, Bengt
Project: Abdominal aortic aneurysms, epidemiology, biomarkers, screening and treatment
5 % of 65-year old men have an abdominal aortic aneurysm. The frequenc............
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Lindgren, Arne
Project: Risk factors and consequences of stroke
This stroke research program includes translational research on molecu............
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Lindvall, Olle
Project: Neurogenesis, cell transplantation and neuroprotection in Parkinson's disease, epilepsy and stroke
During the past two decades both experimental and clinical studies hav............
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Ljung, Rolf
Project: COAGULATION DISORDERS IN CHILDREN
Haemophilia A and B are hereditary, X chromosomal recessive bleeding d............
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Ljungh, Åsa
Project: Biomaterials - protein adsorption, microbial adhesion and effects on biological systems
Biomaterials, mainly polymers and metals, are implanted for temporary ............
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Lohmander, Stefan
Project: From gene to patient: risk factors, disease mechanisms, biomarkers and treatment of osteoarthritis
Osteoarthritis (OA) represents a major disease burden to individual an............
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Lundberg, Cecilia
Project: Development of gene therapy methods to treat damage and disease in the CNS
The limited healing capacity of the central nervous system makes it an............
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Lundborg, Göran
Project: Nerve injury and brain plasticity
Peripheral nerve injuries represent one of the most difficult reconstr............
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Lundwall, Åke
Project: Studies on proteins and genes expressed in male accessory sex glands
The primary aim of our research is to elucidate the role of seminal pl............
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Löfqvist, Anders
Project: Sources of sound in speech
Human speech is the most importan means of communication. For all spee............
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Magnusson, Måns
Project: Quantification of human postural control, reflexive eye movements and development of therapies for disturbed balance and dizziness
To maintain balance and to orientate in the surroundings we use sensor............
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Malm, Johan
Project: Proteins in seminal plasma and on spermatozoa; their function and significance for normal fertility and prostate cancer.
Infertility affects approximately one in seven couples in Sweden and i............
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Malmsjö, Malin
Project: Effects of ischemia on the neuroretina and retinal arteries
Retinal ischemia due to local circulatory failure in diabetes, vein th............
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Malmström, Anders
Project: Functions and biosynthesis of proteoglycans and their effect on tissue remodeling
The aim of the project is to increase the understanding of composition............
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Mani, Katrin
Project: Novel therapeutic aspects of cancer and neurodegenerative disease by targeting glycans.
Our research focuses on the structural biology of glypican-1, a ............
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Massoumi, Ramin
Project: The role of ubiquitylation enzymes in cancer
Post-translational modification including ubiquitiylation of the............
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Mattiasson, Anders
Project: Lower urinary tract dysfunction
Lower urinary tract dysfunction affects several hundred millions of su............
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Mattsson, Ragnar
Project: Role of cartilage oligomeric matrix protein (COMP) and COMP-dependent storage of vitamin D in arthritis
The aim of the present project proposal is to investigate the role of ............
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Mattsson, Sören
Project: Development and optimisation of radiation based methods for diagnosis and therapy of patients
The research is divided in 3 sub-projects: 1. OPTIMISATION............
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McNeil, Thomas
Project: Psychiatric Risk Research: Risk Factors for Psychosis and their Importance for Treatment and Prevention
Evidence suggests that events early in the individual';s life pla............
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Melander, Olle
Project: INTEGRATION OF GENOMICS AND BIOMARKERS AS A TOOL TO IMPROVE PREDICTION AND TREATMENT OF CARDIOVASCULAR DISEASE
Cardiovascular disease (CVD) is the major cause of mortality and disab............
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Merlo, Juan
Project: Socioeconomic and geographical disparities in health and health care utilisation - a longitudinal and contextual (multilevel and spatial) analysis
Many studies have shown differences in the social distribution of heal............
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Mertens, Fredrik
Project: Cytogenetic and molecular genetic studies of bone and soft tissue tumors
Tumor cells are characterized by acquired genetic changes, many of whi............
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Mitelman, Felix
Project: Database of chromosome aberrations in cancer
Chromosome investigations have revealed characteristic and tumor-............
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Mulder, Hindrik
Project: Metabolic control of insulin secretion
Diabetes Mellitus is caused by an absolute or relative deficiency of i............
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Månsson, Wiking
Project: Experimental and clinical aspects of bladder cancer
Bladder cancer, most often transitional cell carcinoma, is the sixth m............
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Mörgelin, Matthias
Project: Supramolecular Structure and Dynamics in Connective Tissues: Modulation of Aggrecan and Collagen VI Network Assembly by Extracellular Matrix Components.
Connective tissues play important roles in the form of three-dimension............
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Nettelbladt, Per
Project: The Lundby Study - 50 years of psychiatric epidemiology
The Lundby Study is a longitudinal survey of the mental health in a to............
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Nettelbladt, Ulrika
Project: The effects on communication of severe language impairment. Studies of mono- and bilingual children with different disabilities.
Three separate subprojects are involved, all of which address children............
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Nilbert, Mef
Project: Molecular Genetics, Tumor Biology and Prognosis in Colorectal Cancer and Soft Tissue Sarcoma
Colorectal cancer represents 12% of the cancer cases, whereas soft tis............
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Nilsson, Bengt-Olof
Project: The importance of vascular estrogen receptors
The female sex hormone estrogen is supposed to have a protective effec............
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Nilsson, Jan
Project: Development of immune-based therapy and diagnostics for atherosclerosis
Atherosclerosis is a chronic disease characterized by intimal inflamma............
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Nilsson, Peter
Project: Diabetes and myocardial dysfunction - epidemiological, pathophysiological and genetic aspects. Early Vascular Ageing (EVA) in a population.
Diabetes and cardiovascular disease are strongly linked, due to sharin............
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Nilsson, Åke
Project: Absorption, metabolism and signalling functions of bioactive lipids in the gut
Colon cancer and inflammatory bowel disease are common diseases caused............
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Nilsson-Ehle, Peter
Project: Hormonal and genetic regulation of lipoprotein metabolism
Hyperlipoproteinemia is one of the major risk factors for cardiovascul............
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Nordander, Catarina
Project: Work-related musculoskeletal disorders
Disease of the musculoskeletal system (i.a. in neck/shoulder/arm) is a............
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Nordström, Carl-Henrik
Project: Cerebral microdialysis during neuro intensive care
The microdialysis technique for continuous sampling of the interstitia............
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Norrgren, Hans
Project: STUDIES OF HIV-1 AND HIV-2 IN GUINEA-BISSAU INCLUDING EFFECTS OF HTLV-1, HEPATITIS B/C, SEXUALLY TRANSMITTED INFECTIONS AND EXPOSURE OF ENVIRONMENTAL POTENTIALLY IMMUNOTOXIC COMPOUNDS
HIV-2 does not show the same explosive epidemiology as HIV-............
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Obrant, Karl
Project: An effort to utilize biochemical markers of bone metabolism with the objective of identifying osteoporosis, predicting osteoporotic fracture and monitoring treatment of osteoporosis.
Osteoporosis has developed into a threat to public health. Identificat............
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Odenholt, Inga
Project: The rationale use of antibiotics; Pharmacokinetics/pharmacodynamics of antibiotics:The importance of PK/PD indices to increase efficacy of antibiotics and to minimize the development of resistance
In spite of more than 50 years of clinical use of antibiotics, the opt............
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Oldberg, Åke
Project: Function and biosynthesis of connective tissue components
The research focuses on the function and biosynthesis of a family of e............
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Olofsson, Per
Project: Antenatal and intrapartum fetal surveillance
The aim of fetal surveillance is to detect deviations from the normal ............
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Olofsson, Tor
Project: Growth regulation of hematopoiesis
Hematopoietic stem cells residing in the bone marrow proliferate and d............
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Olsson, Bertil
Project: Atrial fibrillation - mechanisms and mechanism-based treatment
The mechanisms responsible for initiation and perpetuation of atrial f............
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Olsson, Håkan
Project: Studies of environmental and genetic factors in patients with malignant tumours
Environmental factors account for most cases of cancer while strong ge............
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Olsson, Inge
Project: Targeting of therapeutic proteins to malignant/inflammatory processes with hematopoietic cells and platelets as carriers
Targeting of effective therapy is important for optimal distribution, ............
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Olsson, Martin L
Project: Histo-blood group molecules as targets for lysis and pathogen attack: Deciphering genetics, structure/function and mechanisms of protection
Many patient categories rely on transfusions for their treatment. The ............
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Olsson, Rolf
Project: Simultaneous videoradiography and solid state intraluminal pharyngeal manometry in the analysis of pharyngeal dysfunction
Dysphagia is the subjective awareness of swallowing difficulties. Seve............
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Orho-Melander, Marju
Project: Genetics of type 2 diabetes, dyslipidemia and cardiovascular disease: translation to clinical practise
Recent genomewide association studies have localized common DNA sequen............
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Owman, Christer
Project: Molecular, functional, pharmaceutical, and clinical aspects of G-protein coupled receptors - focus on inflammation and life-style diseases
G-protein coupled receptors (GPCRs) form the most important rece............
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Parmar, Malin
Project: Cell fate specification of neural stem and progenitor cells
The main goal in our laboratory is to understand the mechanisms contro............
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Passant, Ulla
Project: The Lund Longitudinal Dementia Study. A neuropsychiatric, neuropsychological, neuroimaging, genetic and neuropathological investigation.
Dementia disease is one of the most important medical and socioeconomi............
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Persson, Jenny L
Project: Cell cycle regulation in leukemia and in prostate cancer and potential utility of novel therapeutic strategies
Our research group is interested in studying the roll of several coope............
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Persson, Lo
Project: Intracellular growth factors
Cellular proliferation, differentiation and death are all processes pl............
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Petersén, Åsa
Project: Neuroendocrine Aspects of Huntington's Disease and Depression
The research group focuses on Huntington';s disease and psychiatr............
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Påhlman, Sven
Project: Characterization of the hypoxic phenotype in solid tumors with focus on HIF-2a and tumor initiating/stem cells
Cellular adaptation to diminished tissue oxygen tensions, known as hyp............
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Rahm Hallberg, Ingalill
Project: Aging, quality of life, care of people with dementia. public care and R CT with case management
Sweden is in the forefront internationally with regard to the relative............
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Rauch, Uwe
Project: Basic mechanisms in mural cell activation in atherosclerotic lesions
Atherosclerosis can be characterized as a chronic inflammatory disease............
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Ridderstråle, Martin
Project: Identification and characterization of candidate genes for human obesity and insulin resistance
The prevalence of obesity and type 2 diabetes (T2DM) is increasing wor............
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Riesbeck, Kristian
Project: Outer membrane proteins from respiratory pathogens - implications for pathogenesis and vaccine development
Haemophilus influenzae and Moraxella catarrhalis are two respiratory p............
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Ringnér, Markus
Project: Development of computational methods in genomics with breast cancer applications
We are involved in a large number of studies aimed to characterize bre............
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Rippe, Bengt
Project: The exchange across capillary walls, with reference to glomerular and peritoneal capillary permeability. Physiological, pathophysiological and clinical aspects
The cells of the body require a constant "internal milieu" p............
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Risberg, Jarl
Project: Mental functions and regional cerebral blood flow - with special emphasis on measurement of white matter blood flow in organic dementia by a new 133-Xe-SPECT method
Measurements of the regional cerebral blood flow have been used by us ............
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Rosén, Ingmar
Project: Neurophysiological correlates of mental activity
We investigate how different parts of the brain are engaged in normal ............
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Rönnstrand, Lars
Project: Molecular mechanisms c-Kit and Flt3 mediated transformation in leukemia and other malignancies
Our work is focused on understanding the mechanisms of signaling of gr............
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Sahlén, Birgitta
Project: Cognition and communication in children with hearing impairment
Two sub-projects addressing cognitive, linguistic and communcative ski............
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Salehi, S Albert
Project: Mechanisms and pharmacological prevention of lipotoxicity and glucotoxicity in pancreatic beta-cells of type 2 diabetes
Endocrine signal systems are an important part of a balanced integrati............
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Salford, Leif
Project: Experimental Neuro-Oncology - research at the Rausing Laboratory, BMC, Lund
Brain tumours constitute one of the largest diagnostic groups treated ............
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Saxne, Tore
Project: Molecular markers for tissue damage in rheumatic diseases - tools for diagnosis and disease monitoring
Rheumatoid arthritis and osteoarthritis lead to tissue destruction. Ot............
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Scheja, Agneta
Project: Fibrosis and microangiopathy in Systemic Sclerosis (SSc): Pathogenesis, prognostic factors and methods for therapy evaluation.
Systemic sclerosis is a rare but serious rheumatic disease that is cha............
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Schmidtchen, Artur
Project: Pathogenesis of skin infections and therapies based on endogenous antimicrobial peptides
In the normal, "healthy" state, we co-exist in an ecological............
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Schouenborg, Jens
Project: Role of spontaneous movements in guiding the functional adaptation of spinal pain related networks
The mechanisms that determine the signal strength in the pain pathways............
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Segelmark, Mårten
Project: Generation of autoantibodies in renal vasculitis
Wegener';s Granulomatosis (WG), Microscopic polyangiitis (MPA) an............
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Semb, Henrik
Project: Pancreas development and directed differentiation of human embryonic stem cells (hESCs) into pancreatic cell lineages.
Directed differentiation of hESCs towards the beta cell fate is curren............
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Siesjö, Peter
Project: Immunotherapy of experimental and human malignant brain tumors
Malignant brain tumors are utterly resistant to conventional treatment............
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Sitnicka, Ewa
Project: Cellular and molecular pathways during early stages of NK cell development
NK cells represent the third lymphoid lineage distinct from T and B ce............
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Sivberg, Bengt
Project: Children and young adults with autism spectrum disorders (ASD). Group homes, Early screening and Early intervention
Despite the fact that there is a great number of families with childre............
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Sjöbring, Ulf
Project: Streptococcal pathogenesis
Group A streptococci (GAS) cause common but relatively mild disease su............
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Sjölander, Anita
Project: Leukotrienes roll in inflammatory induced cancer: How does leukotrienes regulate cell survival and proliferation in intestinal epithelial cells?
It is known that inflammatory conditions such as ulcerative colitis ca............
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Skerfving, Staffan
Project: Public health impact of long-term, low level mixed element exposure in susceptible population strata (PHIME)
Exposure to metals is a problem in the work and general environments. ............
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Sorokin, Lydia
Project: Cell-matrix interactions in endothelial cell differentiation and function, with emphasis on inflammatory processes and secondary lympahtic organs
Basement membranes are specialized extracellular matrices that underli............
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Steen, Stig
Project: New techniques for increasing lung transplantation frequency
The worldwide shortage of organ donors results in limited possibilitie............
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Strand, Sven-Erik
Project: Systemic Radiation Therapy and Dosimetry with SPECT and PET Quantitative Imaging and Treatment Planning . Clinical and Preclinical (Lund University Bio Imaging Center) Therapy optimization for enhanc
Disseminated cancer with wide spread micro metastases will have the op............
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Sturfelt, Gunnar
Project: Studies on long term prognosis and on the etiology and immunopathogenesis of systemic lupus erythematosus (SLE)
We have established a well characterized incepient cohort of SLE with ............
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Ståhlberg, Freddy
Project: Development of methodology for functional in vivo magnetic resonance imaging (MRI) studies of circulation and molecular motion at 3 tesla.
In Lund, two 3 tesla (T) magnetic resonance imaging (MRI) units are av............
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Sundler, Frank
Project: Peptidergic signal systems
Many physiological functions in the gastro-entero-pancreat............
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Sundler, Roger
Project: Molecular aspects of macrophage function
The innate immune system plays important roles in the defence against ............
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Svanborg, Catharina
Project: A. Molecular microbial pathogenesis - B. HAMLET; a protein folding variant inducing tumour cell apoptosis
A. Microbial pathogenesis The host response to infection ca............
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Swärd, Karl
Project: Role of lipid rafts and caveolae in vascular wall function
Lipid rafts are planar aggregates of cholesterol and specific lipds th............
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Sörensen, Ole E
Project: Role of antimicrobial (poly)peptides in the innate immune response
The skin and other epithelia not only serve as simple physical barrier............
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Tapper, Hans
Project: New approaches to phagocyte membrane traffic research
Professional phagocytes, e.g. macrophages and neutrophils, destroy bac............
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Tennvall, Jan
Project: Targeted Cancer Therapy (especially antibody therapy) with Radioactive Isotopes
Only a minority of patients with disseminated malignant tumors can be ............
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Thorlacius, Henrik
Project: Gastrointestinal Inflammation and Immunity
............
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Thorngren, Karl-Göran
Project: Bone healing processes in the elderly. Optimised hip fracture treatment.
Fractures in the elderly is the largest orthopedic treatment area. Eve............
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Tingström, Anders
Project: Effects of antidepressant and mood stabilizing treatment on cellular plasticity
BACKGROUND: Severe mood disorders are associated with a 10-15% m............
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Toresson, Håkan
Project: Investigation of neuronal calcium homeostasis involving the calcium store
It has been hypothesised for a long time that structural alterations w............
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Torffvit, Ole
Project: Diabetic Nephropathy
Diabetic nephropathy is the most expensive and worst disease for diabe............
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Tranberg, Karl-Göran
Project: Interstitial laser thermotherapy of tumours
The aim is to investigate how interstitial laser thermotherapy (ILT) e............
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Truedsson, Lennart
Project: Complement-dependent mechanisms in immune defence and autoimmune disease
The complement systems may be regarded as a link between innate and ad............
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Träskman Bendz, Lil
Project: Psychobiological studies of affect, stress, and suicidal behaviour
Mood disorders are among the leading causes of disability worldwide. T............
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Tägil, Magnus
Project: Pharmacological and Mechanical Modulation of the Bone Healing Response in Fracture Repair, Osteonecrosis and Prosthetic Loosening. Clinical and Experimental Studies.
The technical progresses for the orthopaedic surgeon treating fracture............
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Valentin, Lil
Project: Gynecological and obstetrical ultrasound including studies of the circulation of female reproductive organs using Doppler ultrasound, three-dimensional (3D) ultrasound, and ultrasound contrast
The aim is to refine the gynecological ultrasound examination includin............
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Wadström, Torkel
Project: Helicobacter pylori and bile-resistant Helicobacter species in the pathogenesis of gastric, hepatic, biliary and pancreatic diseases
Helicobacter pylori has emerged as one of the most commonly occurring ............
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Wennerberg, Johan
Project: Squamous cell carcinoma of the head and neck - clinical and experimental studies
The incidence of H&N ca. in Sweden is approx. 1200 cases/yr. World wid............
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Westergren-Thorsson, Gunilla
Project: Human Lung Repair in Chronic Inflammation
Airway remdoelling can be described as a wound healing process, which ............
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Widell, Anders
Project: Molecular, clinical and epidemiological studies on hepatitis B virus, hepatitis C virus and GB-virus C infections with special referenece to primary liver cancer and viral interactions
Two related blood borne flaviviruses; hepatitis C virus (HCV) and GB v............
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Widner, Håkan
Project: Clinical experimental therapies in neuro-degenerative and -inflammatory diseases
The projects aim at transferring preclinical results into a clinical............
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Wieloch, Tadeusz
Project: Studies on the mechanisms of brain damage and functional recovery following stroke
The brain requires a continuous delivery of oxygen and glucose in orde............
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Wieslander, Jörgen
Project: Pathogenic, diagnostic and therapeutic studies of autoantibody associated systemic vasculitis
Systemic vasculitis is a group of diseases with severe, acute inflamma............
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Wirestam, Ronnie
Project: Assessment of perfusion using magnetic resonance imaging (MRI): Physics and methodology
The aims of this project are to develop MRI pulse sequences and post............
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Wirfält, Elisabet
Project: Nutrition and Cancer Epidemiology
As much as 70 percent of all cancer could be related to diet (Doll & P............
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Xu, Cang-Bao
Project: Cardiovascular Risk Factors and Intracellular Signaling
Cardiovascular disease has long remained the number one killer in the ............
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Zygmunt, Peter
Project: TRANSIENT RECEPTOR POTENTIAL (TRP) ION CHANNELS - NOVEL DRUG TARGETS IN THE SENSORY NERVOUS SYSTEM
Sensory nerves expressing the Transient Receptor Potential (TRP) ion c............
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Åkerström, Bo
Project: Studies of a radical-scavenger and antioxidant, alpha-1-microglobulin
Alpha-1-microglobulin (A1M) participates in heme metabolis............
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Åkesson, Anita
Project: Immune mechanism in systemic sclerosis (SSc, scleroderma). Studies of T-cell-fibroblast interaction and cytokine profiles
Systemic sclerosis (SSc, scleroderma) is an autoimmune disease of unkn............
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Åkesson, Kristina
Project: Genetic regulation of bone metabolism and disease: genetic variation and bone mass, bone turnover and fracture.
The aim of this project is to improve risk assessment by evaluating ge............
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Öhlin, Ann-Kristin
Project: Thrombomodulin in health and disease
In the western world, large patient groups suffer from venous or arter............
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Östergren, Per-Olof
Project: Determinants for recent trends in population health: The development of theory and method for socioepidemiological surveillance and analysis for support of health promotion
International socioepidemiological research has increasingly focused o............
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