Laboratory and clinical studies with focus on physiology and lung protective ventilation in the Acute Respiratory Distress Syndrome
Principal investigator; Jonson, Björn, Professor, MD/PhD
Clinical speciality: Clinical physiology
Phone: ++4646173335
Co-workers, Lund University: Bodelsson Mikael, Malmkvist Gunnar
Research area/areas: Clinical Laboratory Medicine, Other Medical Biotechnology, Physiology, Radiology, Nuclear Medicine and Medical Imaging, Respiratory Medicine and Allergy
Our advanced and unique techniques, e.g. computer controlled ventilators are applied in patient studies and in the animal lab. Clinical applications in intensive care are based upon European cooperation. Objectives are to penetrate how gas exchange and lung mechanics are perturbed in the adult respiratory distress syndrome (ARDS)and on that basis define and test rational modes of ventilation offering optimalprotection agasint ventilation induced lung injury.
Gas exchange and lung mechanics are studied at controlled flow rate that is modulated in a sinusoidal way to allow separation of elastic and resistive pressure. An animal model of ARDS is used to test a new concept of lung protective ventilationbased upon individual tuning of the ventilation to prevalent physiological status. Modes of ventilation which enhances CO2 exchange are developed and tested in order to reduce tidal volume and thereby offer optimal lung protection.
ARDS remains one of the most important causes of death in intensive care. Ventilation induced lung injury is one of the reasons. The lung damaging mechanisms are known. It is also understood how each of these mechanisms may be suppressed. However, no rational comprehensive principle about how to ventilate in a way adapted to the acutal physiology of the patient and suppressing all damaging mechanisms has been described. This project is addressing this complex issue and has come far towards an efficient approach.
Link to project homepage: http://www.klinfys.lu.se/avdkf
5 recent original publications
Bitzén Ulrika, Niklason Lisbet, Göransson Ingegerd, Jonson Björn
Measurement and mathematical modelling of elastic and resistive lung mechanical properties studied at sinusoidal expiratory flow.
Clinical physiology and functional imaging. 2010; 30: 439-46
Bitzen U, Enoksson J, Uttman L, Niklason L, Johansson L, Jonson B
Multiple pressure-volume loops recorded with sinusoidal low flow in a porcine acute respiratory distress syndrome model
Clin Physiol Funct Imaging. 2006; 26: 113-9
Devaquet Jerome, Jonson Björn, Niklason Lisbet, Larbi Anne-Gaelle Si, Uttman Leif, Aboab Jerome, Brochard Laurent
Effects of inspiratory pause on CO2 elimination and arterial PCO2 in acute lung injury
Journal of Applied Physiology. 2008; 105: 1944 - 1949
De Robertis Edoardo, Uttman Leif, Jonson Björn
Re-inspiration of CO2 from ventilator circuit: effects of circuit flushing and aspiration of dead space up to high respiratory rate
Critical Care. 2010; 14: -
Devaquet Jerome, Jonson Björn, Niklason Lisbet, Larbi Anne-Gaelle Si, Uttman Leif, Aboab Jerome, Brochard Laurent
Effects of inspiratory pause on CO2 elimination and arterial PCO2 in acute lung injury
Journal of Applied Physiology. 2008; 105: 1944 - 1949
Further publications here (new window)