Role of SADB kinases in cell division and cancer
Principal investigator; Alvarado-Kristensson, Maria, Assistant Professor, PhD
Clinical speciality:
Phone: ++4640338391
Co-workers:
The group's interest is to find novel target proteins that are involved in cell cycle regulation and whose activities result in cancer development. Until now, our research has been focused on the function of a group of Ser/Thr kinases named SADB. In a non-transformed cell, SADB:s normal action is to preserve genome stability during cell cycle. Disturbed activity of SADB leads to formation of transformed cells containing an increased or decreased DNA content. In our body, these transformed cells will continue to divide. After each cell cycle, the cells can further suffer from DNA changes and they become genetically unstable. Continued uncontrolled cell division will lead to tumor formation. Our group wants to describe the mechanisms by which SADB kinase activity contributes to tumor formation.
Link to project homepage: http://www.med.lu.se/english/labmedmalmo/molecular_pathology
5 recent original publications
Greta Höög, Reihaneh Zarrizi, Kristina Jonsson, Kristoffer von Stedingk and Maria Alvarado-Kristensson
Nuclear localization of Gamma-tubulin affects E2F transcriptional activity and S-phase progression
The FASEB journal. 2011; 25: 3815-3827
Maria Alvarado Kristensson, María Josefa Rodríguez, Virginia Sílio, José M. Valpuesta and Ana Carrera
SadB kinases mediated g-tubulin phosphorylation regulates centrosome duplication
Nature Cell Biology. 2009; 11: 1081-1092
Ana C. Carrera and Maria Alvarado-Kristensson
SADB kinases licence centrosome replication
Cell Cycle. 2009; 8: 4-5
Further publications here (new window)
Financing/year
| Total financing: | 2.0 MSEK | Gov grant for clinical research ("ALF"): | 0.0 MSEK | |
| Total external financing: | 2.0 MSEK | Natl and intl prioritized grants: | 0.0 MSEK |