Faculty of Medicine

Lund University

Outer membrane proteins from respiratory pathogens - implications for pathogenesis and vaccine development

Principal investigator; Riesbeck, Kristian, Professor, MD/PhD

Clinical speciality: Clinical bacteriology and virology, Infectious diseases

Phone: +040-338494

Co-workers, Lund University: Deknuydt Florence, Fleury Christophe, Nordström Therése, Singh Birendra

Respiratory tract infections are a common health problem and cause 2-3 millions medical care visits per year only in Sweden. The three most frequently isolated bacteria in such infections are Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. Today a vaccine against pneumococci is included in the general vaccination program for children in Sweden. Our research is focused on H. influenzae and M. catarrhalis and their interactions with the human host. We are particularly interested in identifying adherence molecules, both on the bacterial side and human counterpart, used to initiate the infection or colonization. In addition, we are studying the mechanisms by which the bacteria interact with, avoid or induce the human immune system in the respiratory tract. Several by us characterized outer membrane proteins of these pathogens are considered promising vaccine candidates. The main beneficiaries for a future vaccine are expected to be the very young and COPD patients since these two groups are the ones with the highest risk of respiratory infections, particularly by H. influenzae.

Link to project homepage: http://www.riesbeck.org

5 recent original publications

Resman F, Ristovski M, Forsgren A, Kaijser B, Kronvall G, Medstrand P, Melander E, Odenholt I, Riesbeck K.
Increase of β-lactam-resistant invasive Haemophilus influenzae in Sweden, 1997 to 2010.
Antimicrob Agents Chemother.. 2012; Aug;56: 4408-15

Schaar Viveka, Nordstrom T, Morgelin M, Riesbeck Kristian
Moraxella catarrhalis outer membrane vesicles carry β-lactamase and promote survival of Streptococcus pneumoniae and Haemophilus influenzae by inactivating amoxicillin.
Antimicrobial Agents Chemotherapy. 2011; 55: 3845-3853

Singh Birendra, Jubair Tamim Al, Förnvik Karolina, Thunnissen Marjolein, Riesbeck Kristian
Crystallization and X-ray diffraction analysis of a novel surface-adhesin protein: protein E from Haemophilus influenzae.
Acta crystallographica. Section F, Structural biology and crystallization communications. 2012; 68: 222 - 226

Singh Birendra, Jalalvand Farshid, Mörgelin Matthias, Zipfel Peter, Blom Anna, Riesbeck Kristian
Haemophilus influenzae protein E recognizes the C-terminal domain of vitronectin and modulates the membrane attack complex.
Molecular microbiology. 2011; May 4: 80-98

Vidakovics Maria Laura A Perez, Jendholm PhD Johan, Mörgelin Matthias, Månsson Anne, Larsson Christer, Cardell Lars-Olaf, Riesbeck Kristian
B cell activation by outer membrane vesicles--a novel virulence mechanism.
PLoS pathogens. 2010; 6: 15;6(1):e1000724.

Further publications here (new window)

Financing/year

Total financing:   5.4 MSEK      Gov grant for clinical research ("ALF"):   1.4 MSEK
Total external financing:   3.1 MSEK      Natl and intl prioritized grants:   1.2 MSEK

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